Zinc is not considered to be toxic or dangerous. It is an essential element for humans, animals and plants [2.85]. The human body contains ca. 2 g of zinc and a daily intake of 15 mg for humans is recommended. The oral LD50 value for rats is >15,000 mg ZnO kg-1 (OECD 401).
Exposure to zinc oxide will mainly take place in the workplace by means of the inhalation and dermal exposure route. Exposure due to handling of solid zinc oxide is in the form of dust.
The individual national occupational exposure limits for dust should be supervised while handling zinc oxide. The so-called zinc fever is caused by ultrafine zinc oxide particles, existing in zinc fumes generated by e. g. welding galvanized steel. Commercial grades ofzinc oxide do not cause this fever. Zinc Oxide has no skin irritating properties, no sensitization potential, is not an eye irritant and there is no evidence of carcenogenicity, genotoxicty and reproduction toxicity in man.
2.3.8