In recent years, an international effort has gained momentum to evaluate the key toxicological and ecotoxicological characteristics of high-production volume substances, defined in the United States as substances with an annual production volume greater than 1 million pounds and in the EU as substances with an annual production volume greater than 1 million kgs. Among HPPs being tested in Eur-
ope are copper phthalocyanine green (C. I. Pigment Green 7), while in the United States Quinacridone Reds 122 and 202 have been selected for possible future testing [10-12]. With the concept of “filling in the blanks,” compiling a “robust” summary of tox/ecotox test results for the authorities to review, and posting this on the internet for all to see, the next few years should greatly expand our understanding of the inherent safety to human health and the environment of high production volume substances, including high-performance pigments.