No adverse toxicological effects were observed in animal tests involving oral and inhalational intake of the pigments.
LD50 rat, oral > 5000 mg/kg
LC50 rat, inhalational > 5.15 mg/L/4 hours
Skin irritation Non-irritant (tested on rabbit)
Mucous-membrane irritation Non-irritant (tested on rabbit’s eye)
Mutagenicity (Ames test) Negative (tested on five strains of bacteria with
and without enzymatic activation) Non-sensitizing (tested on guinea pig)
2.6.2