Polyether polyols are generally considered to be low in toxicity with respect to eye and skin irritation; however, amine-initiated polyether polyols have been found to be more irritating to the skin and eyes. The manufacturer’s material safety data sheet (MSDS) should always be consulted before use. Oral toxicity is generally a secondary concern in an industrial environment. The vapor pressure of polyols is generally negligible; thus vapor inhalation is not usually a concern [41]. Low-molecular-weight glycols (chain extenders) are considered more problematical than polyether polyols. While generally the vapor pressure of these products is low, there are processes that could potentially result in vapor concentrations close to the exposure limits [41]. The exposure guidelines for chain extenders may be written to differentiate between aerosols and vapors. For more specific handling information the manufacturer should be consulted.
The toxicology of isocyanates is a primary concern when developing or using polyurethane adhesives. Respiratory effects are the primary toxicological manifestation of repeated overexposure to diisocyanates [42-46]. In addition, most of the monomeric isocyanates are eye and skin irritants. Precautions should be taken in the workplace to prevent exposure. The risk of overexposure is primarily (but not limited to) allergic sensitization with asthma-type symptoms. Manufacturers’ guidelines (MSDS) should be consulted for the most current information and legal requirements.