Industrial Hygiene of pMDI Resins

All isocyanate containing compounds are highly reactive and potentially toxic. Care should be taken to prevent stored isocyanates from reacting with water because the resulting CO2 could produce dangerous pressures in sealed containers. Consequently, isocyanates are often stored under nitrogen gas or anhydrous air. Contact with all isocyanates should be avoided, especially inhalation. Fortunately, pMDI resins have low vapor pressures, which means that inhalation is easy to avoid under typical laboratory conditions. The greatest concern is during industrial processes when the resins are sprayed. Spraying creates aerosols that could lead to allergic sensitization from inhalation. Under current industrial practice, all spraying is conducted in sealed containers so that aerosols are safely controlled. Inhalation exposure is a risk near hotpressing operations due to high temperature volatilization. Consequently, proper ventilation and isolation are required near the hotpress. In practice, ventilation and isolation precautions are also commonly employed at the resin blenders and forming line. It is easy and safe to use pMDI resins when exercising standard precautions to avoid dermal contact and inhalation. Adequate ventilation should be assured when hotpressing pMDI bonded materials under research or pilot scale conditions. Otherwise, respirators and protective clothing are required. Professional industrial hygiene personnel can easily evaluate laboratory and pilot scale operations for airborne pMDI.

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