Лако-красочные материалы — производство

Most animal cell membrane surfaces are covered with glycoproteins and glycolipids extending from the cell exterior [13]. Collectively, all the polysaccharide structures on the outer surface of the cell are referred to as the glycocalyx [14]. The glycocalyx is continually being synthesized by the underlying cells [14] and is thought to be partly responsible for the adhesive property of the cell. Like mucus, the surface of cell mem­branes has a net negative charge due to the presence of charged groups [8,9], and the binding of mucin to the cell layer then results primarily from interaction between two surfaces of the same charge with additional secondary forces providing stabilization. The primary adhesive force for most bioadhesives is thought to be hydrogen bonding.

Adherence of a drug delivery system directly to any mucosal membrane can occur if the mucus layer is disturbed or the bioadhesive penetrates the mucin. Disruption of the mucus layer can be by abrasion, cell sloughing, chemical alterations by mucolytic agents, or disease state of the tissue [15]. If such an interruption occurs, bioadhesives can serve (1) to maintain continuity of the mucus layer and minimize the exposed area, (2) replace the mucus layer and provide a protective covering for the underlying cell layers from physical and chemical injury, and (3) act as a platform for drug delivery to local tissues and facilitate recovery of the damaged or diseased cell layers.