Toxicology

Titanium dioxide is highly stable and is regarded as completely nontoxic. Investiga­tions on animals, which have been fed TiO2 over a long period give no indication of titanium uptake [2.68]. Absorption of finely divided TiO2 pigments in the lungs does not have any TiO2-related specific carcinogenic effect [2.72].

Generally, inhalation of smaller particles into the lung is more detrimental com­pared to larger particles. But there are no known specific chemical reactions of TiO2 resulting in inflammation [2.68].

A more detailed outline of the toxicological effects of TiO2 with a helpful list of labeling, registration and permission requirements can be found in Ref. [2.68].

2.2

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