APPLICATIONS

Along with the physicochemical characteristics of the bioadhesive and mucin-epithelium surface, physiological events in the area in which adhesion occurs must be addressed to optimize the drug delivery system. Most delivery systems utilizing bioadhesives are designed to be topically applied to a targeted tissue. Drug delivery systems using bioad­hesives can be applied to many areas of the body, such as the oral cavity, gastric, intest­inal, rectal, vaginal, ocular, and dermal areas. Each tissue type has its own unique properties which can be exploited for the delivery of drugs. Each biological membrane has its own permeability, enzymatic activity, and immunology, which have to be taken into consideration if both satisfactory bioadhesion and improved bioavailability of drug are to be achieved.

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